Description
The Transforming Growth Factors (TGFs) are multifunctional peptides that regulate growth and differentiation in a variety of cells. Recent data suggests that individual TGF-beta isoforms (TGF-beta1, -beta2 and –beta3) have overlapping, yet distinct biological actions and target cell specificities, both in developing and adult tissues. TGF-beta3 is a new isoform that is presumed to play an important role in wound repair and scarring. TGF-beta3 is also thought to be involved in osteoblast proliferation, chemotaxis, and collagen synthesis. Recombinant human TGF-beta3 is a non-glycosylated, disulfide-linked homodimer, containing two 112 amino acid chains